Modelling Age and Sex Differences in Cytochrome P450 Metabolism in the Brain and Liver: Implications for Drug Therapy and Neurodegenerative Diseases

(UofT Team, Started May 1, 2024)

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In this project, we investigate the metabolism of cytochrome P450 (CYP) enzymes in the liver and brain, focusing on age and sex differences. The study highlights the liver's primary metabolic role and the brain's significant function in metabolizing therapeutic drugs and neurotoxins linked to neurodegenerative diseases. We aim to analyze in vivo drug metabolism, and tissue drug levels in a controlled environment. The drugs studied include Coumarin (CYP2A6), Chlorzoxazone (CYP2E1), Dextromethorphan (CYP2D6), Bupropion (CYP2B6), and Nicotine, which serve as probe substrates. Insights from this research could profoundly impact personalized medical treatments, optimizing drug dosing, and reducing risks associated with drug abuse and neurodegeneration. (Prof. Rachel Tyndale, Prof. Meghan Chenoweth)

 

 

 

 

 

 

 

 

 

 

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Studying the Genetic Liability Between Tobacco Use and Schizophrenia for Treatment Strategies and Drug Discovery (UofT Team, Started Jan8,2024)

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